Envejecimiento cerebral y Neurodegeneración English version

Dalmasso MC, de Rojas I, Olivar N, Muchnik C, Angel B, Gloger S, Sanchez Abalos MS, Chacón MV, Aránguiz R, Orellana P, Cuesta C, Galeano P, Campanelli L, Novack GV, Martinez LE, Medel N, Lisso J, Sevillano Z, Irureta N, Castaño EM, Montrreal L, Thoenes M, Hanses C, Heilmann-Heimbach S, Kairiyama C, Mintz I, Villella I, Rueda F, Romero A, Wukitsevits N, Quiroga I, Gona C, Lambert JC, Solis P, Politis DG, Mangone CA, Gonzalez-Billault C, Boada M, Tàrraga L, Slachevsky A, Albala C, Fuentes P, Kochen S, Brusco LI, Ruiz A, Morelli L, Ramírez A. (2024). The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer’s disease. Alzheimer’s & Dementia?: The Journal of the Alzheimer’s Association, 20(2), 1298–1308. https://doi.org/10.1002/alz.13522 Pubmed

Galeano P, de Ceglia M, Mastrogiovanni M, Campanelli L, Medina-Vera D, Campolo N, Novack GV, Rosell-Valle C, Suárez J, Aicardo A, Campuzano K, Castaño EM, Do Carmo S, Cuello AC, Bartesaghi S, Radi R, Rodríguez de Fonseca F, Morelli L. The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis. International Journal of Molecular Science Nov 30;24(23):17009. (2023) doi: 10.3390/ijms242317009. PubMed

Dalmasso MC, Arán M, Galeano P, Perin S, Giavalisco P, Martino Adami PV, Novack GV, Castaño EM, Cuello AC, Scherer M, Maier W, Wagner M, Riedel-Heller S, Ramirez A, Morelli L. Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics. Front Mol Biosci. 9:1067296 (2023). doi: 10.3389/fmolb.2022.1067296. PubMed

Ruiz-Viroga V, de Ceglia M, Morelli L, Castaño EM, Calvo EB, Suárez J, de Fonseca FR, Galeano P, Lagos P. Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. Prog Neuropsychopharmacol Biol Psychiatry. 123:110703 (2023). doi: 10.1016/j.pnpbp.2022.110703. PubMed

Bellenguez C, et EADB Group (Castaño EM, Morelli L). New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 54(4):412-436 (2022). doi: 10.1038/s41588-022-01024-z. PubMed

de Rojas I, EADB contributors, The GR@ACE study group, DEGESCO consortium, IGAP, PGC-ALZ consortia, et al. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 12(1):3417 (2021). doi: 10.1038/s41467-021-22491-8. PubMed

Novack GV, Galeano P, Castaño EM, Morelli L. Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders. Front Endocrinol. 11:600 (2020). doi: 10.3389/fendo.2020.00600. PubMed

Bocai NI, Marcora MS, Belfiori-Carrasco LF, Morelli L, Castaño EM. Endoplasmic Reticulum Stress in Tauopathies: Contrasting Human Brain Pathology with Cellular and Animal Models. J Alzheimers Dis. ;68(2):439-458 (2019). doi: 10.3233/JAD-181021. PubMed

Dalmasso MC, Brusco LI, Olivar N, Muchnik C, Hanses C, Milz E, Becker J, Heilmann-Heimbach S, Hoffmann P, Prestia FA, Galeano P, Avalos MSS, Martinez LE, Carulla ME, Azurmendi PJ, Liberczuk C, Fezza C, Sampaño M, Fierens M, Jemar G, Solis P, Medel N, Lisso J, Sevillano Z, Bosco P, Bossù P, Spalletta G, Galimberti D, Mancuso M, Nacmias B, Sorbi S, Mecocci P, Pilotto A, Caffarra P, Panza F, Bullido M, Clarimon J, Sánchez-Juan P, Coto E, Sanchez-Garcia F, Graff C, Ingelsson M, Bellenguez C, Castaño EM, Kairiyama C, Politis DG, Kochen S, Scaro H, Maier W, Jessen F, Mangone CA, Lambert JC, Morelli L, Ramirez A. Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease. Transl Psychiatry. 9(1):55 (2019). doi: 10.1038/s41398-019-0394-9. PubMed

Martino Adami PV, Nichtová Z, Weaver DB, Bartok A, Wisniewski T, Jones DR, Do Carmo S, Castaño EM, Cuello AC, Hajnóczky G, Morelli L. Perturbed mitochondria-ER contacts in live neurons modelling Alzheimer's disease amyloid pathology. J Cell Sci. 132(20). pii: jcs229906 (2019). doi: 10.1242/jcs.229906. PubMed

Prestia FA, Galeano P, Martino Adami PV, Do Carmo S, Castaño EM, Cuello AC, Morelli L. Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer. Neurochem Res. 44(6):1375-1386 (2019). doi:10.1007/s11064-018-2657-x. PubMed

Galeano P, Leal MC, Ferrari CC, Dalmasso MC, Martino Adami PV, Farías MI, Casabona JC, Puntel M, Do Carmo S, Smal C, Arán M, Castaño EM, Pitossi FJ, Cuello AC, Morelli L. Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer. Mol Neurobiol. 55(11):8637-8650 (2018). doi: 10.1007/s12035-018-1002-3. PubMed

Castelletto V, Ryumin P, Cramer R, Hamley IW, Taylor M, Allsop D, Reza M, Ruokolainen J, Arnold T, Hermida-Merino D, Garcia CI, Leal MC, Castaño E. Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives. Sci Rep. 7:43637 (2017). doi: 10.1038/srep43637. PubMed

Frenkel L, Muraro NI, Beltrán González AN, Marcora MS, Bernabó G, Hermann-Luibl C, Romero JI, Helfrich-Förster C, Castaño EM, Marino-Busjle C, Calvo DJ, Ceriani MF. Organization of Circadian Behavior Relies on Glycinergic Transmission. Cell Rep. 19:72-85 (2017). doi: 10.1016/j.celrep.2017.03.034. PubMed

Marcora MS, Belfiori-Carrasco LF, Bocai NI, Morelli L, Castaño EM. Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. Neurobiol Aging. 24;60:57-70 (2017). doi: 10.1016/j.neurobiolaging.2017.08.012. PubMed