Estructura-Función e Ingeniería de Proteínas English version
Borkosky Susana S, Fassolari M, Campos-León K, Hugo Rossi A, Salgueiro M, Antonela Pascuale C, Peralta Martínez R, Gaston K, de Prat Gay G. Biomolecular condensation of the human papillomavirus E2 master regulator with p53: Implications in viral replication. J Mol Biol. (2023 in Press). doi: 10.1016/j.jmb.2022.167889. PubMed
Salgueiro M, Camporeale G, Visentin A, Aran M, Pellizza L, Esperante SA, Corbat A, Grecco H, Sousa B, Esperón R, Borkosky SS, de Prat-Gay G. Molten globule driven and self-downmodulated phase separation of a viral factory scaffold. J Mol Biol. (2023 in Press). doi: 10.1016/j.jmb.2023.168153. PubMed
Sierra AA, Loureiro ME, Esperante S, Borkosky SS, Gallo GL, de Prat Gay G, Lopez N. Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain. Viruses. 15(9):1818. (2023) doi: 10.3390/v15091818. PubMed
Visentin A, Demitroff N, Salgueiro M, Borkosky SS, Uversky VN, Camporeale G, de Prat-Gay G. Assembly of the Tripartite and RNA Condensates of the Respiratory Syncytial Virus Factory Proteins In Vitro: Role of the Transcription Antiterminator M2-1. Viruses. 15(6):1329 (2023). doi: 10.3390/v15061329. PubMed
Esperante SA, Alvarez-Paggi D, Salgueiro M, Desimone MF, de Oliveira GAP, Arán M, García-Prado J, Aptekmann AA, Ventura S, Alonso LG, Prat-Gay G. A finely tuned interplay between calcium binding, ionic strength and pH modulates conformational and oligomerization equilibria in the Respiratory Syncytial Virus Matrix (M) protein. Arch Biochem Biophys. 731:109424 (2022). doi: 10.1016/j.abb.2022.109424. PubMed
González Foutel NS, Glavina J, Borcherds WM, Safranchik M, Barrera-Vilarmau S, Sagar A, Estaña A, Barozet A, Garrone NA, Fernandez-Ballester G, Blanes-Mira C, Sánchez IE, de Prat-Gay G, Cortés J, Bernadó P, Pappu RV, Holehouse AS, Daughdrill GW, Chemes LB. Conformational buffering underlies functional selection in intrinsically disordered protein regions. Nat Struct Mol Biol. 29(8):781-790 (2022). doi: 10.1038/s41594-022-00811-w. PubMed
Lopez N, Camporeale G, Salgueiro M, Borkosky SS, Visentín A, Peralta-Martinez R, Loureiro ME, de Prat-Gay G. Deconstructing virus condensation. PLoS Pathog. 17(10):e1009926 (2021). doi: 10.1371/journal.ppat.1009926. PubMed Review
Leroy L, Barbosa JARG, de Prat-Gay G, Polikarpov I, Pinheiro CB. The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1. Proteins. 88(1):106-112 (2020). doi: 10.1002/prot.25773. PubMed
Alvarez Paggi D, Esperante SA, Salgueiro M, Camporeale G, de Oliveira GAP, Prat Gay G. A conformational switch balances viral RNA accessibility and protection in a nucleocapsid ring model. Arch Biochem Biophys. 671:77-86 (2019). doi: 10.1016/j.abb.2019.06.005. PubMed
Alvarez-Paggi D, Lorenzo JR, Camporale G, Montero L, Sánchez IE, de Prat Gay G, Alonso LG. Topology dictates evolution of regulatory cysteines in a family of viral oncoproteins. Mol Biol Evol. 36(7):1521-1532 (2019). doi: 10.1093/molbev/msz085. PubMed
Conci J, Alvarez-Paggi D, de Oliveira GAP, Pagani TD, Esperante SA, Borkosky SS, Aran M, Alonso LG, Mohana-Borges R, Prat-Gay G. Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus. Biochemistry. 58(26):2883-2892 (2019). 10.1021/acs.biochem.8b01288. PubMed
Leroy LMD, Barbosa JARG, de Prat-Gay G, Polikarpov I, Pinheiro CB. The structure of the extended E2 DNA-binding domain of the Bovine Papillomavirus-1. Proteins. 88(1):106-112 (2019). doi: 10.1002/prot.25773. PubMed
Esperante SA, Alvarez-Paggi D, Salgueiro M, Prat Gay G. Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2-1 Transcription Antiterminators. ACS Omega. 3(11):14732-14745 (2018). doi:10.1021/acsomega.8b01600. PubMed
Glavina J, Román EA, Espada R, de Prat-Gay G, Chemes LB, Sánchez IE. Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein. Virology. 525:117-131 (2018). doi: 10.1016/j.virol.2018.08.012. PubMed
Molina IG, Esperante SA, Marino Buslje C, Chemes LB, de Prat-Gay G. Cooperative RNA recognition by a viral transcription antiterminator. J Mol Biol. 430(6):777-792 (2018). doi: 10.1016/j.jmb.2018.01.018. PubMed