Inmunología y Microbiología Molecular English version
Iglesias Rando MR, Gorojovsky N, Zylberman V, Goldbaum FA, Craig PO. Improvement of Cellulomonas fimi endoglucanase CenA by multienzymatic display on a decameric structural scaffold. Appl Microbiol Biotechnol. 107(13):4261-4274 (2023). doi: 10.1007/s00253-023-12581-6. PubMed
Llauger G, Melero R, Monti D, Sycz G, Huck-Iriart C, Cerutti ML, Klinke S, Mikkelsen E, Tijman A, Arranz R, Alfonso V, Arellano SM, Goldbaum FA, Sterckx YGJ, Carazo JM, Kaufman SB, Dans PD, Del Vas M, Otero LH. A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers. mBio. 14(2):e0002323 (2023). doi: 10.1128/mbio.00023-23. PubMed
Farizano Salazar DH, Achinelli F, Colonna M, Pérez L, Giménez AA, Ojeda MA, Miranda Puente SN, Sánchez Negrette L, Cañete F, Martelotte Ibarra OI, Sanguineti S, Spatz L, Goldbaum FA, Massa C, Rivas M, Pichel M, Hiriart Y, Zylberman V, Gallego S, Konigheim B, Fernández F, Deprati M, Roubicek I, Giunta DH, Nannini E, Lopardo G, Belloso WH; EPIC Study Group. Safety and effectiveness of RBD-specific polyclonal equine F(ab´)2 fragments for the treatment of hospitalized patients with severe Covid-19 disease: A retrospective cohort study. PLoS One.17(9):e0274796 (2022). doi: 10.1371/journal.pone.0274796. PubMed
Salinas F, Marelli BE, Sanguineti S, Goldbaum F, Muñoz L, Etchevers L, Silvestrini P, Notaro US, Salvetti NR, Zylberman V, Ortega HH. Non-clinical safety assessment and in vivo biodistribution of CoviFab, an RBD-specific F(ab')2 fragment derived from equine polyclonal antibodies. Toxicol Appl Pharmacol. 434:115796 (2022). doi: 10.1016/j.taap.2021.115796. PubMed
Srinivasan L, Alzogaray V, Selvakumar D, Nathan S, Yoder JB, Wright KM, Klinke S, Nwafor JN, Labanda MS, Goldbaum FA, Schön A, Freire E, Tomaselli GF, Amzel LM, Ben-Johny M, Gabelli SB. Development of High affinity Nanobodies Specific for NaV1.4 and NaV1.5 Voltage-Gated Sodium Channel Isoforms. J Biol Chem. 298(4):101763 (2022). doi: 10.1016/j.jbc.2022.101763. PubMed
Conforte V, Otero LH, Toum L, Sirigu S, Antelo GT, Rinaldi J, Foscaldi S, Klinke S, Chavas LMG, Vojnov AA, Goldbaum FA, Malamud F, Bonomi HR. Pr-favoured variants of the bacteriophytochrome from the plant pathogen Xanthomonas campestris hint on light regulation of virulence-associated mechanisms. FEBS J. 288(20):5986-6002 (2021). doi: 10.1111/febs.15883. PubMed
Farias A, Soto A, Puttur F, Goldin CJ, Sosa S, Gil C, Goldbaum FA, Berguer PM. A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment. Sci Rep. 11(1):15406 (2021). doi: 10.1038/s41598-021-94837-7. PubMed
Lopardo G, Goldbaum FA, et al, on behalf ofINM005 Study Group. RBD-specific polyclonal F(ab´)2 fragments of equine antibodies in patients with moderate to severe COVID-19 disease: A randomized, multicenter, double-blind, placebo-controlled, adaptive phase 2/3 clinical trial. EClinicalMedicine. 34:100843 (2021). doi: 10.1016/j.eclinm.2021.100843. PubMed
Moran MC, Bence AR, Vallecillo MFS, Lützelschwab CM, Rodriguez MG, Pardo R, Goldbaum FA, Zylberman V, Palma SD, Maletto BA, Estein SM. Polymeric antigen BLSOmp31 formulated with class B CpG-ODN in a nanostructure (BLSOmp31/CpG-ODN/Coa-ASC16) administered by parenteral or mucosal routes confers protection against Brucella ovis in Balb/c mice. Res Vet Sci. 135:217-227 (2021). doi: 10.1016/j.rvsc.2021.02.011. PubMed
Otero LH, Foscaldi S, Antelo GT, Rosano GL, Sirigu S, Klinke S, Defelipe LA, Sánchez-Lamas M, Battocchio G, Conforte V, Vojnov AA, Chavas LMG, Goldbaum FA, Mroginski MA, Rinaldi J, Bonomi HR. Structural basis for the Pr-Pfr long-range signaling mechanism of a full-length bacterial phytochrome at the atomic level. Sci Adv. 7(48):eabh1097 (2021). doi: 10.1126/sciadv.abh1097 PubMed
Rinaldi J, Fernández I, Shin H, Sycz G, Gunawardana S, Kumarapperuma I, Paz JM, Otero LH, Cerutti ML, Zorreguieta Á, Ren Z, Klinke S, Yang X, Goldbaum FA. Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase. mBio. 12(2):e00264-21 (2021). doi: 10.1128/mBio.00264-21. PubMed
Antelo GT, Sánchez-Lamas M, Goldbaum FA, Otero LH, Bonomi HR, Rinaldi J. A Spectroscopy-based Methodology for Rapid Screening and Characterization of Phytochrome Photochemistry in Search of Pfr-favoured Variants. Photochem Photobiol. 96(6):1221-1232 (2020). doi: 10.1111/php.13313. PubMed
Cacciari RD, Reynoso A, Sosa S, Parodi F, Goldbaum FA, Montejano HA, Biasutti MA, Reynoso E. Effect of UVB solar irradiation on Laccase enzyme: evaluation of the photooxidation process and its impact over the enzymatic activity for pollutants bioremediation. Amino Acids. 52(6-7):925-939 (2020). doi: 10.1007/s00726-020-02861-0. PubMed
Pellizza L, López JL, Vázquez S, Sycz G, Guimarães BG, Rinaldi J, Goldbaum FA, Aran M, Mac Cormack WP, Klinke S. Structure of the putative long tail fiber receptor-binding tip of a novel temperate bacteriophage from the Antarctic bacterium Bizionia argentinensis JUB59. J Struct Biol. 212(1):107595 (2020). doi: 10.1016/j.jsb.2020.107595. PubMed
Torres N, Regge MV, Secchiari F, Friedrich AD, Spallanzani RG, Raffo Iraolagoitia XL, Núñez SY, Sierra JM, Ziblat A, Santilli MC, Gilio N, Almada E, Lauche C, Pardo R, Domaica CI, Fuertes MB, Madauss KP, Hance KW, Gloger IS, Zylberman V, Goldbaum FA, Zwirner NW. Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein. J Immunother Cancer. 8(1):e000233 (2020). doi:10.1136/jitc-2019-000233. PubMed