Mariano Salgueiro

Biotecnólogo, egresado de la Universidad Nacional de Quilmes (2015). Becario doctoral bajo la dirección del Dr. Gonzalo de Prat Gay. Mi objeto de estudio es el mecanismo de ensamblado del complejo de replicación y transcripción del virus respiratorio sincicial.

Borkosky Susana S, Fassolari M, Campos-León K, Hugo Rossi A, Salgueiro M, Antonela Pascuale C, Peralta Martínez R, Gaston K, de Prat Gay G. Biomolecular condensation of the human papillomavirus E2 master regulator with p53: Implications in viral replication. J Mol Biol. (2023 in Press). doi: 10.1016/j.jmb.2022.167889.      PubMed

Salgueiro M, Camporeale G, Visentin A, Aran M, Pellizza L, Esperante SA, Corbat A, Grecco H, Sousa B, Esperón  R, Borkosky SS, de Prat-Gay G. Molten globule driven and self-downmodulated phase separation of a viral factory scaffold. J Mol Biol. (2023 in Press). doi: 10.1016/j.jmb.2023.168153.      PubMed

Sierra AA, Loureiro ME, Esperante S, Borkosky SS, Gallo GL, de Prat Gay G, Lopez N. Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain. Viruses. 15(9):1818. (2023) doi: 10.3390/v15091818. PubMed

Visentin A, Demitroff N, Salgueiro M, Borkosky SS, Uversky VN, Camporeale G, de Prat-Gay G. Assembly of the Tripartite and RNA Condensates of the Respiratory Syncytial Virus Factory Proteins In Vitro: Role of the Transcription Antiterminator M2-1. Viruses. 15(6):1329 (2023). doi: 10.3390/v15061329.      PubMed

Esperante SA, Alvarez-Paggi D, Salgueiro M, Desimone MF, de Oliveira GAP, Arán M, García-Prado J, Aptekmann AA, Ventura S, Alonso LG, Prat-Gay G. A finely tuned interplay between calcium binding, ionic strength and pH modulates conformational and oligomerization equilibria in the Respiratory Syncytial Virus Matrix (M) protein. Arch Biochem Biophys. 731:109424 (2022). doi: 10.1016/j.abb.2022.109424.      PubMed

González Foutel NS, Glavina J, Borcherds WM, Safranchik M, Barrera-Vilarmau S, Sagar A, Estaña A, Barozet A, Garrone NA, Fernandez-Ballester G, Blanes-Mira C, Sánchez IE, de Prat-Gay G, Cortés J, Bernadó P, Pappu RV, Holehouse AS, Daughdrill GW, Chemes LB. Conformational buffering underlies functional selection in intrinsically disordered protein regions. Nat Struct Mol Biol. 29(8):781-790 (2022). doi: 10.1038/s41594-022-00811-w.     PubMed

Lopez N, Camporeale G, Salgueiro M, Borkosky SS, Visentín A, Peralta-Martinez R, Loureiro ME, de Prat-Gay G. Deconstructing virus condensation. PLoS Pathog. 17(10):e1009926 (2021). doi: 10.1371/journal.ppat.1009926.      PubMed      Review

Leroy L, Barbosa JARG, de Prat-Gay G, Polikarpov I, Pinheiro CB. The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1. Proteins. 88(1):106-112 (2020). doi: 10.1002/prot.25773.      PubMed

Alvarez Paggi D, Esperante SA, Salgueiro M, Camporeale G, de Oliveira GAP, Prat Gay G. A conformational switch balances viral RNA accessibility and protection in a nucleocapsid ring model. Arch Biochem Biophys. 671:77-86 (2019). doi: 10.1016/j.abb.2019.06.005.     PubMed

Alvarez-Paggi D, Lorenzo JR, Camporale G, Montero L, Sánchez IE, de Prat Gay G, Alonso LG. Topology dictates evolution of regulatory cysteines in a family of viral oncoproteins. Mol Biol Evol. 36(7):1521-1532 (2019). doi: 10.1093/molbev/msz085.      PubMed

Conci J, Alvarez-Paggi D, de Oliveira GAP, Pagani TD, Esperante SA, Borkosky SS, Aran M, Alonso LG, Mohana-Borges R, Prat-Gay G. Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus. Biochemistry. 58(26):2883-2892 (2019). 10.1021/acs.biochem.8b01288.       PubMed

Leroy LMD, Barbosa JARG, de Prat-Gay G, Polikarpov I, Pinheiro CB. The structure of the extended E2 DNA-binding domain of the Bovine Papillomavirus-1. Proteins. 88(1):106-112 (2019). doi: 10.1002/prot.25773.      PubMed

Esperante SA, Alvarez-Paggi D, Salgueiro M, Prat Gay G. Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2-1 Transcription Antiterminators. ACS Omega. 3(11):14732-14745 (2018). doi:10.1021/acsomega.8b01600.      PubMed

Glavina J, Román EA, Espada R, de Prat-Gay G, Chemes LB, Sánchez IE. Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein. Virology. 525:117-131 (2018). doi: 10.1016/j.virol.2018.08.012.      PubMed

Molina IG, Esperante SA, Marino Buslje C, Chemes LB, de Prat-Gay G. Cooperative RNA recognition by a viral transcription antiterminator. J Mol Biol. 430(6):777-792 (2018). doi: 10.1016/j.jmb.2018.01.018.      PubMed